What’s the difference between miRNA and siRNA

  • In general, siRNA mediates RNAi in an exogenous manner, whereas miRNA mediates RNAi in an endogenous manner.
  • siRNA always binds with full complementarity to its target mRNA (degradation of target mRNA); miRNA can also bind with incomplete complementarity to its target (disturbs translation of mRNA).
  • Biogenesis of siRNA and miRNA is different since their origin is different: before miRNA reaches maturity, it must undergo extensive post-transcriptional modifications.
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